With the two Madrid clubs - Atletico and Real - not playing until Sunday, Gerardo Martino's men can temporarily move three points clear at the summit with a victory.
Barca returned to winning ways against Malaga last time out in the league, having been held to draws in their previous two fixtures.
And history weighs heavily in the hosts' favour in this fixture, with Valencia returning winless from Barca's home ground in all visits since 2003.
